Cholinergic hyperactivity and negative symptoms: behavioral effects of physostigmine in normal controls

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Cholinergic hyperactivity and negative symptoms: behavioral effects of physostigmine in normal controls.

Intravenous infusion of physostigmine (a centrally active anticholinesterase agent) in normal subjects leads to a syndrome of psychomotor inhibition; this has been proposed as a model for selected symptoms of depression. In view of its similarity to the negative schizophrenic syndrome, we compared the 'physostigmine syndrome' to the negative symptom profile by evaluating the behavioral effects ...

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ژورنال

عنوان ژورنال: Schizophrenia Research

سال: 1993

ISSN: 0920-9964

DOI: 10.1016/0920-9964(93)90004-3